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NEWS
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2007

October 2007
The paper investigating the role of alpha-synuclein in oxidative stress was accepted for publication.
-Yu, W.H., Matsuoka, Y., Sziraki, I., Hashim, A., LaFrancois, J., Sershen, H. and Duff, K.E. Increased dopaminergic neuron sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in transgenic mice expressing mutant A53T alpha-synuclein. Journal of Neurochemistry, in press.

August 2007
The paper investigating the effects of deglycosylated antibodies in Abeta sequestration therapy and microglial phagocytosis was accepted for publication.
-Takata, K., Hirata-Fukae, C., Becker, A.G., Chishiro, S., Gray, A.J., Nishitomi, K., Franz, A.H., Sakaguchi, G., Kato, A., Mattson, M.P., LaFerla, F.M., Aisen, P.S., Kitamura, Y. and Matsuoka, Y. Deglycosylated anti-amyloid beta antibodies induce amyloid beta sequestration with reduced microglial phagocytosis and cytokine release. European Journal of Neuroscience,
26: 2458-2468. [download].

May  2007
Dr. Niikura, PhD, DVM, a new faculty member, joined.
Ms. Elkhansa (Hansa) Sidahmed, MS, a new research associate, joined.

March  2007
Dr. Matsuoka presented deglycosylated antibody project at an international meeting
Matsuoka, Y., Takata, K., Hirata-Fukae, C., Becker A.G., Chishiro, S., Gray, A.J., Mattson, M.P., LaFerla, F.M., Aisen, P.S. and Kitamura, Y. Deglycosylated antibodies for Abeta sequestration. 8th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD 2007). March 2007, Salzburg, Austria.

February  2007
The paper investigating effects of a neuronal tubulin interacting agent in a AD transgenic mice was published.
-Matsuoka, Y., Gray, A.J., Hirata-Fukae, C., Minami, S.S., Waterhouse, E.G., Mattson, M.P., LaFerla, F.M., Gozes, I. and Aisen, P.S. (2007) Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer’s disease at early pathological stage. Journal of Molecular Neuroscience, 31: 165-170. Covered by Alzforum. [download]

The paper investigating effects of C terminus Abeta antibody in a AD transgenic mice was published.
-Gray, A.J., Sakaguchi, G., Shiratori, C., Becker, A.G., LaFrancois, J., Aisen, P.S., Duff, K. and Matsuoka, Y. (2007) Antibody against C-terminus Abeta selectively elevate plasma Abeta. NeuroReport, 18: 293-296. [download]

January  2007
New 5-year NIH research grant (R01) was awarded to Dr. Matsuoka. [Link]

 

2006

October  2006
Matsuoka lab presents posters at Society for Neuroscience meeting in Atlanta.
-Gray, A.J., Takata, K., Kitamura, Y., Hirata-Fukae, C., Aisen, P.S., and Matsuoka, Y. Deglycosylated antibody sequesters Abeta without enhancing Abeta phagocytosis.
-Horikoshi, Y., Hirata-Fukae, C., Gray, A.J., Aisen, P.S., Nishitomi, K., Sakaguchi, G., Kinoshita, N. and Matsuoka, Y. Method to evaluate Abeta-lowering strategies in wildtype (non-transgenic) mice using newly developed Abeta ELISA.
-Minami, S., Hoe, H, Matsuoka, Y. and Rebeck G.W. Modulation of APP processing by Fyn.
-Bernardo, A., McCord, M., Thompson, R., Davies, S.S., Roberts III, L.J., Mathews, P., Matsuoka, Y. and McDonald, M.P. Ganglioside reduction improves memory deficits and reduces plaque formation in a mouse model of Alzheimer's disease.

August 2006
The paper investigating the BACE1 as a therapeutic target has been accepted for publication in Journal of Neurochemistry.
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Nishitomi, K., Sakaguchi, G., Horikoshi, Y., Gray, A.J., Maeda, M., Hirata, C., Becker, A.G., Hosono, M., Sakaguchi, I., Nakajima, Y., Kitahara, T., Ota, A., Wong, P.C., Aisen, P.S., Kato, A., Kinoshita, N. and Matsuoka, Y. BACE1 inhibition reduced endogenous Abeta and altered APP processing in wildtype mice in vivo. Journal of Neurochemistry, in press.

July  2006
Matsuoka lab presents posters at The 10th International Conference on Alzheimer’s Disease and Related Disorders, in Madrid, Span.
-Matsuoka, Y., Gray, A., Li, H-L., Hirata, C., Planel, E., Duff, K., Mattson, M.P., Gozes, I. and Aisen, P.S. NAP reduces phosphorylated tau in AD transgenic mice.
-Horikoshi, Y., Hirata, C., Gray, A., Maeda, M., Wong, P.C., Aisen, P.S., Kinoshita, N. and Matsuoka, Y. Development of full-length mouse amyloid beta ELISA and determination of endogenous Abeta level in BACE1 knockout mice.
-Sakaguchi, G., Nishitomi, K., Horikoshi, Y., Nakajima, Y., Hosono, M., Sakaguchi, I., Kihara, T., Aisen, P.S., Kato, A., Kinoshita, N. and Matsuoka, Y. BACE1 inhibition reduces Abeta production and alters APP processing in non-transgenic mice.

The study investigating a tubulin binding agent (NAP) in Alzheimer's pathology has been accepted for publication.
-Matsuoka, Y., Gray, A.J., Hirata-Fukae, C., Minami, S.S., Waterhouse, E.G., Gozes, I. and Aisen, P.S. NAP reduces accumulation of amyloid peptide and tau hyperphosphorylation with early stage treatment of a transgenic mouse model of Alzheimer’s disease. Journal of Molecular Neuroscience, in press

June  2006
Dr. Matsuoka's new 5-year NIH grant proposal (total budget: 1.94 million) ranked at 6.3 percentile. Funding is anticipated to start in December.

Dr Matsuoka presents a paper at The Joint Meeting Summer Neuropeptide Conference and The European Neuropeptide Club. in Miami Beach, FL.
-NAP prevents Alzheimer’s pathology in AD model mouse.

April  2006
New paper was accepted for publication. [Link]
Loftus, T.*, Li, H-F.*, Gray, A.J., Hirata-Fukae, C., Stoica, B., Futami, J., Yamada, H., Aisen, P.S., and Matsuoka, Y. In vivo protein transduction to the central nervous system. Neuroscience, 139: 1061-1067. (*equal contribution) [download]

March 2006
Matsuoka lab presented posters at 8th Annual Alzheimer’s Disease, Drug Discovery and Development, Novel advances in Discovery, Therapeutics, & Clinical trial, in Boston.
-Horikoshi, Y., Hirata, C., Gray, A.J., Wong, P.C., Aisen, P.S., Kinoshita, N. and Matsuoka, Y. Endogenous mouse Abeta is reduced in BACE1 knockout mice.

January 2006
New paper was accepted for publication. [Link]
Loftus, T.*, Li, H-F.*, Gray, A.J., Hirata-Fukae, C., Stoica, B., Futami, J., Yamada, H., Aisen, P.S., and Matsuoka, Y. In vivo protein transduction to the central nervous system. Neuroscience, in press.

 

2005

December 2005
New paper was accepted for publication. [Link]
-Gozes, I., Morimoto, B.H., Tiong, J., Fox, A., Sutherland, K., Dangoor, D., Holser-Cochav, M., Vered, K., Newton, P., Aisen, P.S., Matsuoka, Y., van Dyck, C.H. and Thal, L. (2005) NAP: research and development of a peptide derived from activity-dependent neuroprotective protein (ADNP). CNS Drug Reviews, 11: 353-368.

November 2005
Matsuoka lab presented posters at Society for Neuroscience meeting in Washington DC.
-Becker, A., Horikoshi, Y., Gray, A., Sakaguchi, G., Aisen, P., Kinoshita, N. and Matsuoka, Y. Development of mouse Abeta ELISA and use for evaluation of Abeta-lowering strategies in non-transgenic mice.
-Hoe, H., Wessner, D., Beffert, U., Becker, A.G., Matsuoka, Y. and Rebeck, G.W. F-spondin interaction with the APOE receptor APOER2 affects processing of APP.
-Nelson, R., Madala Halagappa, V., Pearson, M., Matsuoka, Y., Brown, M., Iyun, T., LaFerla, F.M., Clark, R.F. and Mattson, M.P. Serotonin-selective reuptake inhibitor ameliorates behavioral deficits and reduces Abeta pathology in 3xTgAD Mice.
-Veerendra Kumar, M.H., Cutler, R.G., Pearson, M., Matsuoka, Y. and Mattson, M.P. Dietary restriction improves memory in the triple-transgenic mouse model of Alzheimer’s disease. 35th Annual Meeting, Society for Neuroscience, November 2005, Washington, D.C., USA.

New paper was published. [Link]
-Hoe, H-S., Wessner, D., Beffert U, Becker, A.G., Matsuoka, Y., and Rebeck G.W. F-spondin interaction with the apoE receptor ApoEr2 affects processing of APP. Molecular and Cellular Biology, 25: 9259-9268.

August 2005
New post-doc, Dr. Hui-Fang (Judy) Li, PhD, is joined. [Link]
New research assistant, Ms. Chiho Hirata, MS, is joined. [Link]
New provisional patent application was filed. [Link]
Research pages are updated. New quick review slides are available. [Link]
New paper is accepted for publication. [Link]
-Hoe, H-S., Wessner, D., Beffert U, Becker, A.G., Matsuoka, Y., and Rebeck G.W. F-spondin interaction with the apoE receptor ApoEr2 affects processing of APP. Molecular and Cellular Biology, in press (accepted on Aug 8).

Summer 2005
Emily Waterhouse (MD/PhD program) and Sakura Minami (IPN PhD program) did rotation at Matsuoka lab. [Link]

February 9, 2005
Summer Intern information is added. [Link]

 

2004

December 17, 2004
Research pages are updated. [Link]

November 28, 2004
A post-doc position is filled. Dr Liam Loftus is arriving in February 2005. [Link]

September 1, 2004
New 5 years NIH grant (
$630,450) is awarded to Dr. Matsuoka. [Link]

August 31, 2004
New lab picture is updated. [Link]
Summer students, Fumitaka Kato and Lena Enck, left the lab. [Comments]

August 10, 2004
Post-doc and research assistant positions are open. [Link]

July 1, 2004
Intramural Research Grant ($20,000) is awarded to Dr. Matsuoka. [Link]

May 11, 2004
Abeta ELISA paper is accepted. This ELISA measures full length Abeta 1-40 and 1-42 (not x-40 or x-42) in various specimens.

Horikoshi, Y., Sakaguchi, G., Becker, A.G., Gray, A.J., Duff, K., Aisen, PS, Yamaguchi, H., Maeda, M., Kinoshita, N. and Matsuoka, Y. (2004) Development of Aβ terminal end specific antibodies and sensitive ELISA for Aβ variant. Biochemical and Biophysical Research Communications, 319: 733-737. [download]

May 1, 2004
Lab web page is open.

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