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PUBLICATIONS
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Sakaguchi, G., Aisen, P.S. and Matsuoka, Y. Testing secretase inhibitors using in vivo models. In: Recent advances in the biology of secretases, key proteases in Alzheimer disease (ed. Araki, W.), Submitted (invited review), October 2007.

Matsuoka, Y., Jouroukhin, Y., Gray, A.J., Ma, L., Hirata-Fukae, C., Li, H-F, Feng, L., Lecanu, L., Walker, B.R., Planel, E., Arancio, O., Gozes, I. and Aisen, P.S. A neuronal microtubule interacting agent, NAP, reduced tau pathology and enhanced cognitive function in a mouse model of Alzheimer’s disease. Under minor revision (Journal of Pharmacological and Experimental Therapeutics), October 2007.

Hoe, H-S., Minami, S.S., Markova, A., Lee J., Hyman, B.T., Matsuoka, Y., and Rebeck, G.W. Fyn modulation of Dab1 effects on APP and ApoER2 processing. Revision submitted (Journal of Biological Chemistry), October 2007.

Yu, W.H., Matsuoka, Y., Sziraki, I., Hashim, A., LaFrancois, J., Sershen, H. and Duff, K.E. Increased dopaminergic neuron sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in transgenic mice expressing mutant A53T alpha-synuclein. Journal of Neurochemistry, in press (October 2007). [download]

Takata, K., Hirata-Fukae, C., Becker, A.G., Chishiro, S., Gray, A.J., Nishitomi, K., Franz, A.H., Sakaguchi, G., Kato, A., Mattson, M.P., LaFerla, F.M., Aisen, P.S., Kitamura, Y. and Matsuoka, Y. (2007) Deglycosylated anti-amyloid beta antibodies induce amyloid beta sequestration with reduced microglial phagocytosis and cytokine release. European Journal of Neuroscience, 26: 2458-2468. [download].

Nelson, R.L., Guo, Z., Halagappa, V.K.,  Pearson, M., Gray, A.J., Matsuoka, Y., Brown, M., Clark, R.F. and Mattson, M.P. (2007) Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice. Experimental Neurology, 205: 166-176. [download]

Halagappa, V.K., Guo Z., Pearson, M., Matsuoka, Y., Cutler, R.G., LaFerla, F.M. and Mattson, M.P. (2007) Intermittent fasting and caloric restriction ameliorate age-related behavior deficits in the triple-transgenic mouse model of Alzheimer’s disease. Neurobiology of Disease, 26: 212-220. [download]

Gray, A.J., Sakaguchi, G., Shiratori, C., Becker, A.G., LaFrancois, J., Aisen, P.S., Duff, K. and Matsuoka, Y. (2007) Antibody against C-terminus Abeta selectively elevate plasma Abeta. NeuroReport, 18: 293-296. [download]

Matsuoka, Y., Gray, A.J., Hirata-Fukae, C., Minami, S.S., Waterhouse, E.G., Mattson, M.P., LaFerla, F.M., Gozes, I. and Aisen, P.S. (2007) Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer’s disease at early pathological stage. Journal of Molecular Neuroscience, 31: 165-170. Covered by Alzforum. [download]

Hoe, H-S., Tran, T.S., Matsuoka, Y., Howell, B. and Rebeck, G.W. (2006) Dab1 and Reelin effects on APP and ApoER2 trafficking and processing. Journal of Biological Chemistry, 281: 35176-35186. [download]

Nishitomi, K., Sakaguchi, G., Horikoshi, Y., Gray, A.J., Maeda, M., Hirata-Fukae, C., Becker, A.G., Hosono, M., Sakaguchi, I., Minami, S.S., Nakajima, Y., Li, H-F, Takeyama, C., Kitahara, T., Ota, A., Wong, P.C., Aisen, P.S., Kato, A., Kinoshita, N. and Matsuoka, Y.  (2006) BACE1 inhibition reduced endogenous Abeta and altered APP processing in wildtype mice in vivo. Journal of Neurochemistry, 99: 1555-1563. [download]

Loftus, T.*, Li, H-F.*, Gray, A.J., Hirata-Fukae, C., Stoica, B., Futami, J., Yamada, H., Aisen, P.S., and Matsuoka, Y. In vivo protein transduction to the central nervous system. Neuroscience, 139: 1061-1067. (*equal contribution) [download]

Gozes, I., Morimoto, B.H., Tiong, J., Fox, A., Sutherland, K., Dangoor, D., Holser-Cochav, M., Vered, K., Newton, P., Aisen, P.S., Matsuoka, Y., van Dyck, C.H. and Thal, L. (2005) NAP: research and development of a peptide derived from activity-dependent neuroprotective protein (ADNP). CNS Drug Reviews, 11: 353-368.

Hoe, H-S., Wessner, D., Beffert U, Becker, A.G., Matsuoka, Y., and Rebeck G.W. (2005) F-spondin interaction with the apoE receptor ApoEr2 affects processing of APP. Molecular and Cellular Biology, 25: 9259-9268. [download].

Shimizu, T., Matsuoka, Y., and Shirasawa, T. (2005) Biological significance of isoaspartate and its repair system. Biological Pharmacological Bulletin, 29: 1590-1596. [download]

Horikoshi, Y., Sakaguchi, G., Becker, A.G., Gray, A.J., Duff, K., Aisen, PS, Yamaguchi, H., Maeda, M., Kinoshita, N. and Matsuoka, Y. (2004) Development of Aβ terminal end specific antibodies and sensitive ELISA for Aβ variant. Biochemical and Biophysical Research Communications, 319: 733-737. [download]

Burns, M., Gaynor, K., Olm, V., Mercken, M., LaFrancois, J., Wang, L., Mathews, M.P., Noble, W., Matsuoka, Y. and Duff, K. (2003) Presenilin redistribution associated with aberrant cholesterol transport enhances ß-amyloid production in vivo Journal of Neuroscience, 23: 5645-5649. [download]

Noble, W.J., Olm, V., Takata, K., Casey, E., O, M., Meyerson, J., Gaynor, K., LaFrancois, J., Wang, L., Kondo, T., Davies, P., Burns, M., Matsuoka, Y., Ahlijanian, M., Lau, L.F. and Duff, K. (2003) CDK5 is a key factor in tau aggregation and tangle formation in vivo. Neuron, 38: 555-565. [download]

Matsuoka, Y., Saito, M., LaFrancois, J., Saito, M., Gaynor, K., Olm, V., Wang, L., Casey, E., Lu, Y., Lemere, C., and Duff, K. (2003) Novel therapeutic approach for the treatment of Alzheimer’s disease by peripheral administration of agents with an affinity to Aß. Journal of Neuroscience, 23: 29-33. [download]

Lemere, C.A., Spooner, E.T., LaFrancois, J., Malester, B., Mori, C., Leverone, J.F., Matsuoka, Y., Taylor, J.W., DeMattos, R., Holtzman, D., Clements, J.T., Selkoe, D.J. and Duff, K. (2003) Evidence for peripheral clearance of cerebral Aß protein following chronic, active Aß immunization in PSAPP Mice. Neurobiology of Disease, 14: 10-18. [download]

Matsuoka, Y., Picciano, M., LaFrancois, and Duff, K. (2001) Fibrillar ß-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer’s disease. Neuroscience, 104: 609-613. [download]

Matsuoka, Y., Vila, M., Lincoln, S., McCormack, A., Picciano, M., Yu, X., Dickson, D., Langston, W.J., McGowan, E., Farrer, M., Hardy, J., Duff, K., Przedborski, S., DiMonte, D.A. (2001) Lack of nigral pathology in transgenic mice expressing human ?-synuclein driven by the tyrosine hydroxylase promoter. Neurobiology of Disease, 8: 535-539. [download]

Matsuoka, Y., Picciano, M., Malester, B., LaFrancois, J., Daeschner, J.M., Olschowka, J.A., Fonseca, M.I., O'Banion, K.M., Tenner, A., Lemere, C.A., and Duff, K. (2001) Inflammatory responses in response to amyloidosis in a transgenic mouse model of Alzheimer’s disease. American Journal of Pathology, 158: 1345-1354. [download]

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COMPLETE LIST OF PUBLICATIONS

2003

Burns, M., Gaynor, K., Olm, V., Mercken, M., LaFrancois, J., Wang, L., Mathews, M.P., Noble, W., Matsuoka, Y. and Duff, K. (2003) Presenilin redistribution associated with aberrant cholesterol transport enhances ß-amyloid production in vivo Journal of Neuroscience, 23: 5645-5649.

Noble, W.J., Olm, V., Takata, K., Casey, E., O, M., Meyerson, J., Gaynor, K., LaFrancois, J., Wang, L., Kondo, T., Davies, P., Burns, M., Matsuoka, Y., Ahlijanian, M., Lau, L.F. and Duff, K. (2003) CDK5 is a key factor in tau aggregation and tangle formation in vivo. Neuron, 38: 555-565.

Baslow, M.H., Suckow, R.F., Gaynor K., Bhakoo, K., Marks, N., Saito M., Saito, M., Duff, K., Matsuoka, Y. and Berg, M.J. (2003) Brain damage results in down-regulation of N-acetylaspartate as a neuronal osmolyte. NeuroMolecular Medicine, 3: 95-104.

Matsuoka, Y., Saito, M., LaFrancois, J., Saito, M., Gaynor, K., Olm, V., Wang, L., Casey, E., Lu, Y., Lemere, C., and Duff, K. (2003) Novel therapeutic approach for the treatment of Alzheimer’s disease by peripheral administration of agents with an affinity to Aß. Journal of Neuroscience, 23: 29-33.

Lemere, C.A., Spooner, E.T., LaFrancois, J., Malester, B., Mori, C., Leverone, J.F., Matsuoka, Y., Taylor, J.W., DeMattos, R., Holtzman, D., Clements, J.T., Selkoe, D.J. and Duff, K. (2003) Evidence for peripheral clearance of cerebral Aß protein following chronic, active Aß immunization in PSAPP Mice. Neurobiology of Disease, 14: 10-18.

2002

Duff, K., Noble, W., Gaynor, K. and Matsuoka, Y. (2002) Organotypic slice cultures from transgenic mice asdisease model systems. Journal of Molecular Neuroscience, 19: 317-320.

2001

Matsuoka, Y., Picciano, M., LaFrancois, and Duff, K. (2001) Fibrillar ß-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer’s disease. Neuroscience, 104: 609-613.

Matsuoka, Y., Vila, M., Lincoln, S., McCormack, A., Picciano, M., Yu, X., Dickson, D., Langston, W.J., McGowan, E., Farrer, M., Hardy, J., Duff, K., Przedborski, S., DiMonte, D.A. (2001) Lack of nigral pathology in transgenic mice expressing human ?-synuclein driven by the tyrosine hydroxylase promoter. Neurobiology of Disease, 8: 535-539.

Matsuoka Y., Aimi Y., Kimura, H., Taniguchi, T., Oomura, Y., Sasaki, K., and Tooyama I. (2001) Demonstration of acidic fibroblast growth factor (FGF-1) in rat adrenal gland. Acta Histochemica et Cytochemica, 34: 129-134.

Matsuoka, Y., Picciano, M., Malester, B., LaFrancois, J., Daeschner, J.M., Olschowka, J.A., Fonseca, M.I., O'Banion, K.M., Tenner, A., Lemere, C.A., and Duff, K. (2001) Inflammatory responses in response to amyloidosis in a transgenic mouse model of Alzheimer’s disease. American Journal of Pathology, 158: 1345-1354.

1999

Matsuoka, Y., Okazaki, M., Heng, Z., Asai, S., Ishikawa, K., and Kitamura, Y. (1999) Phosphorylation of c-Jun and its colocalization with heme oxygenase-1 and cyclooxygenase-2 in CA1 pyramidal neurons after transient forebrain ischemia. Journal of Cerebral Blood Flow and Metabolism, 19: 1247-1255.

Okazaki, M., Kitamura, Y., and Matsuoka, Y. (1999) Low-affinity kainate receptor subunit-specific agonist, (2S, 4R)-4-methylglutamate (SYM-2081), does not induce neuronal cell death in rat hippocampal formation. Journal of Brain Science, 25: 3-10.

Matsuoka, Y., Okazaki, M., and Kitamura, Y. (1999) Induction of inducible heme oxygenase (HO-1) in the central nervous system: Is HO-1 helpful or harmful? Neurotoxicity Research, 1: 113-117.

Matsuoka, Y., Okazaki, M., Takata, K., Kitamura, Y., Ohta, S., Sekino, Y., and Taniguchi, T. (1999) Endogenous adenosine protects CA1 neurons from kainic acid-induced neuronal cell loss in the rat hippocampus. European Journal Neuroscience, 11: 3617-3625.

Matsuoka, Y., Okazaki, M., Kitamura, Y., Takata, K., Tooyama, I., Kimura, H., and Taniguchi, T. (1999) Kainic acid-induced inducible cyclooxygenase and c-Jun phosphorylation in the rat hippocampal formation. Brain Research, 836: 213-217.

Matsuoka, Y., Okazaki, M., Kitamura, Y., and Taniguchi, T. (1999) Developmental expression of P-glycoprotein (multidrug resistance gene product) in the rat brain. Journal of Neurobiology, 39: 383-392.

Matsuoka, Y., Kitamura, Y., Kakimura, J., and Taniguchi, T. (1999) Expression of heme oxygenase-1 mediated by non-NMDA and metabotropic receptors in glial cells: possible involvement of reactive oxygen species production and protein kinase C activation. Neuropharmacology, 38: 825-834.

Kitamura, Y., Kakimura, J., Matsuoka, Y., Nomura, Y., Gebicke-Haerter, P.J., and Taniguchi, T. (1999) Activators of peroxisome proliferator-activated receptor-gamma (PPARgamma) inhibit inducible nitric oxide synthase expression but increase heme oxygenase-1 expression in rat glial cells. Neuroscience Letters, 262: 129-132.

Matsuoka, Y., Kitamura, Y., Takahashi, H., Tooyama, I., Kimura, H., Gebicke-Haerter, P.J., Nomura, Y., and Taniguchi, T. (1999) Interferon-gamma plus lipopolysaccharide induction of delayed neuronal apoptosis in rat hippocampus. Neurochemistry International, 34: 91-99.

Kitamura, Y., Shimohama, S., Koike, H., Kakimura, J., Matsuoka, Y., Nomura, Y., Gebicke-Haerter, P.J., and Taniguchi, T. (1999) Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer's disease brains. Biochemical and Biophysical Research Communications, 254: 582-586.

Kitamura, Y., Ota, T., Matsuoka, Y., Tooyama, I., Kimura, H., Shimohama, S., Nomura, Y., Gebicke-Haerter, P.J., and Taniguchi, T. (1999) Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cells. Glia, 25: 154-164.

Matsuoka, Y., Kitamura, Y., Okazaki, M., Terai, K., and Taniguchi, T. (1999) Kainic acid-induced activation of nuclear factor-kappaB in rat hippocampus. Experimental Brain Research, 124: 215-222.

1998

Kitamura, Y., Furukawa, M., Matsuoka, Y., Tooyama, I., Kimura, H., Nomura, Y., and Taniguchi, T. (1998) In vitro and in vivo induction of heme oxygenase-1 in rat glial cells: possible involvement of nitric oxide production from inducible nitric oxide synthase. Glia, 22: 138-148.

Kitamura, Y., Kosaka, T., Kakimura, J.I., Matsuoka, Y., Kohno, Y., Nomura, Y., and Taniguchi, T. (1998) Protective effects of the antiparkinsonian drugs talipexole and pramipexole against 1-methyl-4-phenylpyridinium-induced apoptotic death in human neuroblastoma SH-SY5Y cells. Molecular Pharmacology, 54: 1046-1054.

Kitamura, Y., Ota, T., Matsuoka, Y., Okazaki, M., Kakimura, J., Tooyama, I., Kimura, H., Shimohama, S., Gebicke-Haerter, P.J., Nomura, Y., and Taniguchi, T. (1998) Kainic acid-induced neuronal loss and glial changes in the hippocampal CA3 of p53-deficient mouse. Neuroscience Letters, 255: 57-60.

Shimohama, S., Fujimoto, S., Sumida, Y., Akagawa, K., Shirao, T., Matsuoka, Y., and Taniguchi, T. (1998) Differential expression of rat brain synaptic proteins in development and aging. Biochemical and Biophysical Research Communications, 251: 394-398.

Kitamura, Y., Matsuoka, Y., Nomura, Y., and Taniguchi, T. (1998) Induction of inducible nitric oxide synthase and heme oxygenase-1 in rat glial cells [review]. Life Sciences, 62: 1717-1721.

Matsuoka, Y., Kitamura, Y., and Taniguchi, T. (1998) Induction of plasminogen in rat hippocampal pyramidal neurons by kainic acid. Neuroscience Letters, 252: 119-122.

Matsuoka, Y., Kitamura, Y., Okazaki, M., Kakimura, J., Tooyama, I., Kimura, H., and Taniguchi, T. (1998) Kainic acid induction of heme oxygenase in vivo and in vitro. Neuroscience, 85: 1223-1233.

Matsuoka, Y., Kitamura, Y., Okazaki, M., Sakata, M., Tsukahara, T., and Taniguchi, T. (1998) Induction of heme oxygenase-1 and major histocompatibility complex antigens in transient forebrain ischemia. Journal of Cerebral Blood Flow and Metabolism, 18: 824-832.

Shimohama, S., Sumida, Y., Fujimoto, S., Matsuoka, Y., Taniguchi, T., Takenawa, T., and Kimura, J. (1998) Differential expression of rat brain phospholipase C isozymes in development and aging. Biochemical and Biophysical Research Communications, 243: 210-216.

Kitamura, Y., Shimohama, S., Kamoshima, W., Ota, T., Matsuoka, Y., Nomura, Y., Smith, M.A., Perry, G., Whitehouse, P.J., and Taniguchi, T. (1998) Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease. Brain Research, 780: 260-269.

1997

Kitamura, Y., Shimohama, S., Ota, T., Matsuoka, Y., Nomura, Y., and Taniguchi, T. (1997). Alteration of transcription factors NF-kappaB and STAT1 in Alzheimer's disease brains. Neuroscience Letters, 237: 17-20.

Matsuoka, Y., Kitamura, Y., Tooyama, I., Kimura, H., and Taniguchi, T. (1997). In vivo hypoxia-induced neuronal damage with an enhancement of neuronal nitric oxide synthase immunoreactivity in hippocampus. Experimental Neurology, 146: 57-66.

Matsuoka, Y., Kitamura, Y., Fukunaga, R., Shimohama, S., Nabeshima, T., Tooyama, I., Kimura, H., and Taniguchi, T. (1997) In vivo hypoxia-induced neuronal damage in dentate gyrus of rat hippocampus: changes in NMDA receptors and the effect of MK-801. Neurochemistry International, 30: 533-542.

Kitamura, Y., Shimohama, S., Kamoshima, W., Matsuoka, Y., Nomura, Y., and Taniguchi, T. (1997). Changes of p53 in the brains of patients with Alzheimer's disease. Biochemical and Biophysical Research Communications, 232: 418-421.

1996

Kitamura, Y., Takahashi, H., Matsuoka, Y., Tooyama, I., Kimura, H., Nomura,Y., and Taniguchi, T. (1996) In vivo induction of inducible nitric oxide synthase by microinjection with interferon-gamma and lipopolysaccharide in rat hippocampus. Glia, 18: 233-243.

1995

Matsuoka, Y., Kitamura, Y., Tsukahara, T., Terai, K., Tooyama, I., Kimura, H., and Taniguchi, T. (1995) Neuroprotective effects of NBQX on hypoxia-induced neuronal damage in rat hippocampus. Neuroreport, 6: 2205-2208.

Hanai, K. and Matsuoka, Y. (1995) Potentiation of tentacle ball formation by a trypsin-like protease and accompanying augmented ingestion in glutathione-induced feeding in Hydra. Zoological Science, 12: 185-193.

1994

Taniguchi, T., Fukunaga, R., Matsuoka, Y., Terai, K., Tooyama, I., and Kimura, H. (1994) Delayed expression of c-fos protein in rat hippocampus and cerebral cortex following transient in vivo exposure to hypoxia. Brain Research, 640: 119-125.

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