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RESEARCH

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"Cure for Alzheimer's disease"--Development of therapeutic approaches and pharmacological agents for treatment of Alzheimer's disease

Ex vivo modeling of neuropathological events

Hunting new genes involved in Abeta plaque pathology

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"Cure for Alzheimer's disease"--Development of therapeutic approaches and pharmacological agents for treatment of Alzheimer's disease

This is currently the primary focus of the laboratory.

Alzheimer’s disease (AD) is a neurodegenerative affliction associated with memory dysfunction. Two classes of drugs are approved by FDA for treatment of AD, and they are effective at some degree. However, effect of currently available medications are only symptomatic and some patients do not tolerate for medications. Disease-modifying agents is desired for cure of AD. We aim to develop therapeutic approaches and pharmacological agents (drugs) based on multiple cascades; sequestration, secretase modulation, and neuroprotection.   Continued....

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Ex vivo modeling of neuropathological events

Abeta plaque formation occurs in the extracellular space, which is not well maintained in a regular cell culture system. As a result, the Matsuoka Lab has developed organotypic slice cultures to reproduce this environment. Ex vivo modeling and transgenic mice carrying pathological genes have been used to examine the development of pathological events in AD and PD. These events include the formation of Abeta plaques, neurofibrillary tangles, and Lewy body pathologies, which will be useful for drug screening and in mechanistic studies.

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Hunting for new genes involved in Abeta plaque pathology

To investigate new genes involved in Abeta plaque development, the Lab has compared different pathological stages using a high throughput gene expression profiling system. Genes that are significantly up or down regulated between the pre and early stages of Abeta plaque formation are candidates for Abeta plaque modulation. Gene chip technology can assess more than 10,000 genes at once, and will be used to profile AD gene expression. The goal is to discover new genes involved in Abeta plaque pathology.

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